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However, SSRIs differ in their potency and selectivity in inhibiting serotonin reuptake and many of them have important effects on other transporters and receptors.Each SSRI has a unique profile of multiple pharmacologic actions, which explains the differences in their efficacy and tolerabilitythe most potent serotonin reuptake blocker, but has a low selectivity for the serotonin reuptake muscarinic cholinergic receptors (most potent blocker of muscarinic receptors among the SSRIs) histamine H1 receptors nitric oxide synthase cytochrome P450 2D6 the second most potent inhibitor of serotonin reuptake and the second most selective blocker of serotonin over noradrenaline uptake dopamine reuptake (more potent dopamine uptake inhibitor than other SSRIs) All the SSRIs are licensed for major depressive disorder and are considered to be the first-line treatments of depression.Each antidepressant produces approximately a 60% overall response rate (ie, at least a 50% reduction in symptoms as a result of treatment).However, some differences in the SSRIs efficacy exist.However, now its marketing status is "Discontinued".Celexa (Citalopram hydrobromide) was approved by the FDA in July 17, 1998.Celexa is manufactured by Forest Pharmaceuticals, Inc.
All selective serotonin reuptake inhibitors have the same principal mechanism of action.
Escitalopram may be superior in efficacy compared with other SSRIs in the treatment of major depressive disorder While SSRIs do not appear to differ in overall tolerability, the reported incidences of specific side effects vary.
Antidepressants have some different pharmacological characteristics, this means that patients may respond differently to certain SSRIs or experience different side effects with different drugs.
SSRIs are called selective because they seem to affect serotonin significantly more than other neurotransmitters.
Thus, the medications work by allowing the body to make the best use of the reduced amounts of serotonin that it has at the time.
In due course, the levels of natural serotonin will rise again, and in some instances the SSRI can be reduced and withdrawn.